The Calgary Guide to Understanding Disease @TheCalgaryGuide
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hypersensitivityreaction c5c9deficiency complement immunity inflammatory type2 type4 typeiv
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Inflammatory Cascade ... Recruitment • Humoral ... #Inflammation # ... pathophysiology ... #immunology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... Allergic reaction ... Initial exposure to allergen ... cells or CTLs -> Inflammation ... #Immunology #pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
the complement cascade ... HypersensitivityReaction #Allergy ... #Immunology #pathophysiology
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
-> Complement cascade ... • Inflammation ... C5C9Deficiency #Complement #pathophysiology ... #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Humoral Immunity ... proliferate and differentiate ... repeat exposure #Humoral ... #Immunity #pathophysiology ... #immunology
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