The Calgary Guide to Understanding Disease @TheCalgaryGuide
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allergy cascade humoral hypersensitivityreaction immunity inflammation inflammatory type2
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... Maculopapular rash #C5C9Deficiency ... #Complement #pathophysiology ... #immunology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... #Inflammation #pathophysiology ... #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... tagged with C3 complement ... proliferate and differentiate ... Humoral #Immunity #pathophysiology ... #immunology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
activates the complement ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
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