The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis signs symptoms complications lupus erythematosus msk systemic agammaglobulinemia allergy cascade gastrointestinal hypersensitivityreaction immunity inflammation inflammatory lfcn manifestations meralgiaparesthetica mucocutaneous
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Erythematosus (SLE ... Osteonecrosis Esp. humeral ... and femoral heads ... Erythematosus #SLE ... Complications #pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Recruitment • Humoral ... #Inflammation #pathophysiology ... #immunology
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
Erythematosus (SLE ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
the pancreas, Vasculitis ... Erythematosus #SLE ... Complications #pathophysiology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Humoral Immunity ... classical pathway (see ... proliferate and differentiate ... #Immunity #pathophysiology ... #immunology
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
deficiency in adaptive humoral ... Agammaglobulinemia #XLinked #pathophysiology ... #immunology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Livedo Reticularis, Vasculitis ... Phenomenon #Lupus #SLE ... Manifestations #pathophysiology
Meralgia paresthetica: Pathogenesis and Clinical Findings Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica •
injury of Lateral Femoral ... MeralgiaParesthetica #MSK #pathophysiology ... #differential #
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