The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms/Complications ... Syndrome #genetics #pathophysiology ... #peds #pediatrics
Opioid Withdrawal: Clinical Findings and Complications
Note: Opioid withdrawal can be extremely uncomfortable, but is rarely life-threatening
Opioid Withdrawal ... Clinical Findings and Complications ... Note: Opioid withdrawal ... combined with withdrawal ... #Opiate #Pathophysiology
Menstrual Cycle Physiology: the Uterine Cycle
The endometrium has receptors for ovarian hormones! Changes in structure and
the progesterone withdrawal ... the progesterone withdrawal ... fertilized) ovum #MenstrualCycle ... #OvarianCycle #pathophysiology
Acute Otitis Media: Pathogenesis and Clinical Findings (in Children)
Upper Respiratory Tract Infection: 
 - Bacterial: Streptococcus
resolve by 72 hours Complications ... #OtitisMedia #pathophysiology ... symptoms #signs #peds
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... endocrinology #peds
Benzodiazepine (BZD) withdrawal: clinical findings and complications

 • Activation of ACC and OFC -> Feelings of
Benzodiazepine (BZD) withdrawal ... clinical findings and complications ... Benzodiazepine #BZD #withdrawal ... #pharmacology #pathophysiology
Alcohol Withdrawal: Clinical Findings and Complications
The onset of alcohol withdrawal generally begins 6-24 hours after the
Alcohol Withdrawal ... Clinical Findings and Complications ... onset of alcohol withdrawal ... Alcohol withdrawal ... #Pathophysiology
Retinopathy of Prematurity: Pathogenesis and clinical findings
Increased metabolic demand of growing eye
-> Excessive VEGF production ->
-> Neovascular complications ... #Prematurity #peds ... #pediatrics #pathophysiology