The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... yrs old; F>M Signs ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Giant Cell (Temporal) Arteritis: Clinical findings and Complications
Signs/Symptoms: 
 - Headache (usually constant, superimposed by waves
Giant Cell (Temporal ... Complications Signs ... Complications #Signs ... #Symptoms #diagnosis ... #Vasculitis
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... inflammation tends to cause ... pathophysiology #signs ... #symptoms #diagnosis ... #ExtraArticular
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Esp. humeral and femoral ... Myopathy (Also caused ... pathophysiology #signs ... #symptoms #diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... periumbilical region), nausea ... #HSP #IgA #Vasculitis ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Viral replication causes ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... visual acuity • Bitemporal ... Overproduction #diagnosis ... #signs #symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings
 • Physical Trauma (esp. to the scaphoid bone with damage
blood supply & the femoral ... ) • Multiple causes ... " #AvascularNecrosis ... pathophysiology #diagnosis ... #signs #symptoms
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
Slipped capital femoral ... pathophysiology #causes ... #symptoms #signs ... #diagnosis #msk
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
portion of the temporal ... hearing loss, nausea ... sinus thrombosis, Temporal ... pathophysiology #signs ... #symptoms #diagnosis