The Calgary Guide to Understanding Disease @TheCalgaryGuide
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diagnosis psychiatry 21hydroxylasedeficiency 21ohd affectivedisorder bipolar feedbackloop genetics gh growthhormone majordepressivedisorder mdd pediatrics pituitary sad seasonal
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings Symptoms (included in DSM 5 criteria) - Present during
Major Depressive ... Disorder (MDD): ... #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms
Seasonal Affective Disorder: Pathogenesis and clinical findings Symptoms (included in the DSM-V) - Two Major Depressive episodes
Seasonal Affective Disorder ... Disorder - Full ... AffectiveDisorder #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms
Bipolar Disorder: Pathogenesis and Clinical Findings • Disruption of emotional homeostasis • Oscillation between mood states
Bipolar Disorder ... maintain this state Depressive ... #MoodDisorders ... #Diagnosis #Pathophysiology ... #Signs #Symptoms
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
pathway -> Incr gene expression ... activates lipolysis Signs ... /Symptoms: • GH ... #FeedbackLoop #endocrinology ... #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
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