The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
RA) or systemic lupus ... / Symptoms: - ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
liver or kidney disease ... Corticosteroid use • Primary ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
yrs old; F>M Signs ... /Symptoms: - Fever ... Temporal #Arteritis #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Vasculitis
Kawasaki Disease: Clinical Findings
Diagnostic Criteria - Fever and 4/5 of the following:
 • Conjunctivitis
 • Polymorphous
Kawasaki Disease ... #Criteria #Diagnosis ... #Pathophysiology ... #Signs #Symptoms ... #Vasculitis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... rare, gestational diseases ... Signs/Symptoms: ... Pretibial myxedema #Primary ... endocrinology #pathophysiology
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... the etiology Signs ... /Symptoms: - Pretibial ... GravesDisease #pathophysiology ... #signs #diagnosis
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
sensory • Before diagnosis ... intervertebral disc disease ... MeralgiaParesthetica #MSK #pathophysiology ... #differential #diagnosis ... #signs #symptoms