The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
the pancreas, Vasculitis ... -> Acute Pancreatitis ... pathophysiology #signs ... #symptoms #diagnosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
yrs old; F>M Signs ... /Symptoms: - Fever ... Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Acute onset of skin ... in the acute phase ... Signs / Symptoms ... pathophysiology #immunology #diagnosis ... #signs #symptoms
Giant Cell (Temporal) Arteritis: Clinical findings and Complications
Signs/Symptoms: 
 - Headache (usually constant, superimposed by waves
Complications Signs ... /Symptoms: - ... Complications #Signs ... #Symptoms #diagnosis ... #Vasculitis
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
the etiology Signs ... /Symptoms: - Pretibial ... pathophysiology #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
warriors") • Acute ... pre-determined etiology Signs ... /Symptoms/Complications ... TendonRupture #diagnosis ... #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Leukocytoclastic vasculitis ... #HSP #IgA #Vasculitis ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic ... , Carditis #Acute ... pathophysiology #diagnosis ... #signs #symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Pathophysiology #Diagnosis ... #Signs #Symptoms ... #Vasculitis
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
Overproduction #diagnosis ... #signs #symptoms ... #endocrinology