The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Gastrointestinal Manifestations ... the pancreas, Vasculitis ... -> Acute Pancreatitis ... Pseudo-Obstruction: Abdominal pain ... pathophysiology #signs #symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Polyarteritis Nodosa (PAN ... swelling - GI Manifestations ... multiplex #PAN ... Diagnosis #Signs #Symptoms ... #Vasculitis
Giant Cell (Temporal) Arteritis: Clinical findings and Complications
Signs/Symptoms: 
 - Headache (usually constant, superimposed by waves
Complications Signs/Symptoms ... or binocular) - Can ... Stroke or TIA-like symptoms ... Complications #Signs #Symptoms ... #diagnosis #Vasculitis
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... blood vessels (vasculitis ... -> Sudden eye pain ... pleuritic chest pain ... pathophysiology #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Mucocutaneous Manifestations ... Livedo Reticularis, Vasculitis ... Mucocutaneous #Manifestations ... diagnosis #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Leukocytoclastic vasculitis ... Colicky abdominal pain ... #HSP #IgA #Vasculitis ... Diagnosis #Signs #Symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
poly-articular joint pain ... Extra-articular manifestations ... • Non-specific Acute-phase ... arthralgia (joint pain ... pathophysiology #signs #symptoms
Schizotypal Personality Disorder (SPD): Pathogenesis and clinical findings
Cognitive-Perceptual
 • Magical thinking - Belief in paranormal or
Suspiciousness - Can ... thought process can ... #Schizotypal #PersonalityDisorder ... Criteria #Signs #Symptoms
Opioid Withdrawal: Clinical Findings and Complications
Note: Opioid withdrawal can be extremely uncomfortable, but is rarely life-threatening
Opioid withdrawal can ... Symptoms can take ... are more acute ... and can persist ... The less acute behavioral
Achilles Tendon Rupture - Pathogenesis and clinical findings
 • The Achilles tendon is 15cm long in
warriors") • Acute ... etiology Signs/Symptoms ... squeeze test) - Pain ... diagnosis #signs #symptoms