The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs ... #symptoms #diagnosis
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... / Symptoms / Complications ... #MSK #pathophysiology ... #diagnosis #symptoms
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
/Symptoms/Complications ... weight-bear • Arthritic ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... #signs #symptoms
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
mutations - Down syndrome ... chromosome 21) Signs ... / Symptoms / Complications ... pathophysiology #geriatrics #diagnosis ... #signs #symptoms
Kawasaki Disease: Clinical Findings
Diagnostic Criteria - Fever and 4/5 of the following:
 • Conjunctivitis
 • Polymorphous
Clinical Findings Diagnostic ... Criteria - Fever ... /Symptoms/Complications ... : - Coronary Arteritis ... #Signs #Symptoms
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
findings - For diagnosis ... their turn • Causes ... AttentionDeficitHyperactiveDisorder #ADHD #BehavioralDisorder ... #symptoms #signs ... #psychiatry #criteria
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
of the Hip • Arthritis ... pathophysiology #causes ... #symptoms #signs ... #diagnosis #msk
Chronic Exertional Compartment Syndrome (CECS)
 • Diagnosis Of CECS requires patient to undergo the same exertional
Exertional Compartment Syndrome ... activity that causes ... criteria for CECS ... #signs #symptoms ... #msk
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
periumbilical region), nausea ... nephrotic/nephritic syndrome ... Arthralgia's (common), arthritis ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: Complications ... bone formation MSK ... pathophysiology #diagnosis ... #signs #symptoms ... #complications