The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Erectile Dysfunction: Pathogenesis

Erectile Dysfunction - Persistent or recurrent inability to achieve an erection sufficient to achieve
trauma, iatrogenic, diabetes ... hyperlipidemia, diabetes ... (penile artery diameter ... #Pathophysiology ... #Urology #Diagnosis
Diabetic Retinopathy: Pathogenesis and clinical findings

Mild Non-proliferative DR
 • Outpouchings of the weakened capillary walls or
Diabetic Retinopathy ... #Retinopathy #Diabetes ... #ophthalmology ... #diagnosis #complications ... #pathophysiology
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Signs / Symptoms / Complications ... • Secondary glaucoma ... Retinoblastoma #pathophysiology ... #ophthalmology
Acute Closed Angle Glaucoma: Pathogenesis and Clinical Findings
OPHTHALMIC EMERGENCY: Early detection is essential, but most patients
Acute Closed Angle Glaucoma ... present with early glaucoma ... Signs / Symptoms / Complications ... #pathophysiology ... #ophthalmology
Diabetic Foot: Pathogenesis and clinical findings
 • Polyol Pathway - Excess glucose enters Polyol pathway ->
Diabetic Foot: Pathogenesis ... increasing cytogenetic dysfunction ... #DiabeticFoot #pathophysiology ... #complications ... #Diabetes
Pituitary Mass Effects - Pathogenesis and Clinical Findings
 • Pituitary turnors are almost always a benign
Signs / Symptoms / Complications ... Hyperprolactinemia • Diabetes ... • Hypothalamic dysfunction ... mnemonic #GLFTAP #pathophysiology
Mixed Urinary Incontinence: Pathogenesis and Clinical Findings

Urgency Urinary Incontinence (UUI) -> Urinary leakage preceded by a
cystitis, UTI), diabetes ... Incr PVR if a complication ... Incontinence #Mixed #Pathophysiology ... Signs #Symptoms #Urology
Primary Open-Angle Glaucoma: Pathogenesis and Clinical Findings
 • Risk factors -> Incr IOP, Incr age, African-American
Primary Open-Angle Glaucoma ... family history, diabetes ... Primary Open-Angle Glaucoma ... #pathophysiology ... #ophthalmology