The Calgary Guide to Understanding Disease @TheCalgaryGuide
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Account created for The Calgary Guide to Understanding Disease - Linking pathophysiology to clinical presentation - http://calgaryguide.ucalgary.ca/
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Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... ) Arteritis: Pathogenesis ... neurological findings #GiantCell ... #Temporal #Arteritis ... #Pathophysiology
Giant Cell (Temporal) Arteritis: Clinical findings and Complications
Signs/Symptoms: 
 - Headache (usually constant, superimposed by waves
Giant Cell (Temporal ... ) Arteritis: Clinical ... Hemorrhages #GiantCell ... #Temporal #Arteritis ... #diagnosis #Vasculitis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Arthralgia, Arthritis ... Esp. humeral and femoral ... Complications #pathophysiology ... #signs #symptoms
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... the pancreas, Vasculitis ... #Erythematosus ... Complications #pathophysiology ... #signs #symptoms
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
: • Systemic Lupus ... • Erythematosus ... the cause: • Arthritis ... Allergy #Immunology #pathophysiology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
like rheumatoid arthritis ... RA) or systemic lupus ... erythematosus ( ... SLE) Signs / Symptoms ... Sjogrens #Syndrome #Pathophysiology
Giant Cell Arteritis (Polymyalgia Rheumatica and Cranial Arteritis): Pathogenesis and Clinical Findings
 - Morning Stiffness (>1
Giant Cell Arteritis ... Weight Loss #Temporal ... CranialArteritis #Pathophysiology ... #Signs #Symptoms ... #Diagnosis #Vasculitis
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Femoral Head Fracture ... lateral hip Signs/Symptoms ... weight-bear • Arthritic ... msk #diagnosis #pathophysiology ... #signs #symptoms
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Subacute cutaneous lupus ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Arthralgia's (common), arthritis ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology ... Diagnosis #Signs #Symptoms