Ravi Singh K @rav7ks
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Academic Hospitalist and Program Director @SinaiBmoreIMRes, Medicine clerkship director GW School of Medicine and Health Sciences RMC at Sinai, Clinical reasoning,Simulation and POCUS enthusiast - https://twitter.com/rav7ks
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Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Endogenous reactivation ... Treatment: Active ... Initiating Treatment ... Inhibitor: • Risk of reactivation ... Diagnosis #Management #Treatment
Tuberculosis Testing

LATENT TB
• LTBI is diagnosed when an asymptomatic patient has a positive TST or IGRA
decrease the risk for reactivation ... developing active infection ... infection • Recent ... viral infections ... LatentTB #ActiveTB #InfectiousDiseases
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Endogenous reactivation ... Treatment: Active ... Initiating Treatment ... Inhibitor: • Risk of reactivation ... Diagnosis #Management #Treatment
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
., HIV), EBV infection ... Etiology: - Infections ... Solid Tumors • Tuberculosis ... NonHodgkins #comparison #oncology ... #differential #hematology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
result from reactivation ... Antimicrobial treatment ... 80% sensitive Tuberculous ... - Hemorrhage, tuberculomas ... opportunistic #InfectiousDiseases
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Mycobacteria (NTM) Infections ... Mycobacterium tuberculosis ... Hematologic malignancy ... patients with typical tuberculosis ... differential #diagnosis #infectiousdiseases
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
, breast CA - Hematologic ... Upper respiratory infection ... gastrointestinal infection ... Treatment: - Systemic ... #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Neutropenia - recurrent infections ... Idiopathic • Infections ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
weeks without infection ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... MAS #Macrophage #Activation ... Diagnosis #Management #Hematology