Dr. Michael Chew @mchew85
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GrepMed Gastroenterology-Hepatology Editor, Academic Hospitalist UC Davis Medical Center Internal Medicine, Yale Gastroenterology Fellow '22
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Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Causes of Severe Acute ... hepatitis - Acute ... biliary obstruction ... Hemochromatosis - Primary biliary ... #Causes #Differential
Gallstone Diseases
1. Asymptomatic Stones 75%
2. Biliary Pain 20%
3. Acute Cholecystitis 10%
4. Mirizzi's Syndrome < 0.1%
5. Cholangitis/
Biliary Pain 20% ... Acute Cholecystitis ... Gallstone #Diseases #differential
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... Potential pitfalls: Lack ... Benign/malignant biliary ... obstruction, Primary biliary ... dechallenge • Acute
Acute Esophageal Necrosis
History: Hematemesis and/or melena (70%), Dysphagia, Epigastric/chest pain, Sepsis
Diagnosis EGD and Biopsy
Differential: Melanosis, Melanoma,
Acute Esophageal ... EGD and Biopsy Differential ... Braghirol @KBrag_MD #Acute ... Esophageal #Necrosis #black
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... include extrahepatic biliary ... LFTs #Abnormal #Algorithm ... Liver #Enzymes #Differential