Dr. Michael Chew @mchew85
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GrepMed Gastroenterology-Hepatology Editor, Academic Hospitalist UC Davis Medical Center Internal Medicine, Yale Gastroenterology Fellow '22
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Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
of Severe Acute Liver ... Injury - Ichemic hepatitis ... - Drug-Induced liver ... - Autoimmune ... hepatitis - Wilson
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Schistosomiasis - Autoimmune ... Nonalcoholic fatty liver
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... ascites), Chronic hepatitis ... steatosis • Autoimmune ... hepatitis #DILI
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... Indications Treatment ... infection with severe liver ... mg/dL) or acute liver ... failure #HepatitisB
Alcoholic Hepatitis - Management Algorithm
1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... can be bridge to Liver ... #Alcoholic #Hepatitis ... Management #Algorithm #treatment
Autoimmune Hepatitis (AIH) Management Algorithm - Induction and Maintenance
 - AIH
 - AIH with Cirrhosis
 -
Autoimmune Hepatitis ... Severe AIH #Autoimmune ... #Hepatitis #AIH ... Management #Algorithm #treatment