31 results
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease Pathophsiology ... in GBA1 gene Clinical ... involvement (type 2 and 3) ... Disease #Diagnosis #Signs ... #Symptoms
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Pathogenesis and Clinical ... spontaneous within 3- ... MeralgiaParesthetica #MSK #pathophysiology ... differential #diagnosis #signs ... #symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Diagnosis and Management ... extrapulmonary cases Clinical ... Signs/Symptoms: ... years - May have signs ... decreased reflexes Pathophysiology
Bullous Pemphigoid - Diagnosis and Management Summary
Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Diagnosis and Management ... Summary Pathophysiology ... epidermis from dermis Clinical ... Signs/Symptoms/ ... phase: tense 1-3
Stone-In-Neck Sign on Gallbladder POCUS

This 40yo F presented with R flank pain. Here is her biliary
Stone-In-Neck Sign ... sign). ... surgery based on her symptoms ... #Sign #POCUS #clinical ... #gallbladder #ultrasound
Emphysematous Cystitis
Epidemiology:
 • Usually middle-aged diabetic women
 • Other RF: neurogenic bladder, urinary tract outlet obstruction,
immune compromise Clinical ... Signs/Symptoms: ... be present or signs ... Pathophysiology: ... KUB or abdominal ultrasound
Heart failure with Reduced Ejection Fraction (HFrEF)
Clinical Presentation
1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
Fraction (HFrEF) Clinical ... More Specific Signs ... Less Specific Signs ... Chest x-ray: signs ... acute HF → no signs
Psoriatic Arthritis: Pathogenesis and Clinical findings

In tendons and connective tissues:
 • Enthesitis  - Pain/tenderness over
Pathogenesis and Clinical ... DIP joints 3. ... PsoriaticArthritis #pathophysiology ... #diagnosis #signs ... #symptoms
Hypertonic Saline for Treatment of Hyponatremic Encephalopathy
1) 100 ml bolus of 3% NaCl over 10 min.
100 ml bolus of 3% ... May repeat until clinical ... Symptoms improve ... urine output for signs ... Saline #Treatment #management