11 results
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... Physical Exam/Signs ... Diagnosis: • ... Agranulocytosis 3.
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Disease 3 ... Antibodies[PCH] 3. ... Hyperbilirubinemia • Elevated ... younger pts) Differential ... hemolytic #anemia #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
affects infants < 3 ... : HLH signs and ... symptoms can mimic ... Low or absent NK cell ... >500 ng/mL • Elevated
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
• Induce blast cell ... if WBC > 5 or elevated ... : >3 symptoms, or ... Moderate > 2/3 and ... initiation • Differential
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... very remarkable w/differential ... elicited after 2-3 ... them, but urgent rheumatology ... #Symptoms #Diagnosis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... • Progressive symptoms ... or proteinase 3 ... Eosinophilia, asthma, chronic ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
or proteinase 3 ... Eosinophilia, asthma, chronic ... Presentation - Systemic Symptoms ... purpura: strong sign ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... sediment, and elevated ... Induced Lupus: • Symptoms ... with Lupus: • Chronic ... #Rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... ingestion • B symptoms ... in 1/3 of patients ... Inflammatory marker elevated ... Immunohistochemical studies (to differentiate
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Pneumonia: • 3 ... • CT: Halo sign ... Constitutional symptoms ... Abdominal pain, chronic ... Hyponatremia • Elevated