21 results
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... Diagnosis Framework ... noninflammatory Signs ... constitutional symptoms ... #Differential #
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
affects infants < 3 ... : HLH signs and ... symptoms can mimic ... >500 ng/mL • Elevated ... agent are the main
Heart failure with Reduced Ejection Fraction (HFrEF)
Clinical Presentation
1. Typical symptoms: dyspnea, orthopnea paroxysmal noctumal dyspnea, fatigue,
Typical symptoms ... Less Typical Symptoms ... : elevated jugular ... : weight gain, lung ... *Chronic HFrEF may
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Agglutinin Disease 3 ... Antibodies[PCH] 3. ... Hyperbilirubinemia • Elevated ... younger pts) Differential ... chills, flank pain
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... Physical Exam/Signs ... Agranulocytosis 3. ... Elevated LDH 5.
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
or nerve root Symptoms ... Joint - Following 3 ... : • Acute or chronic ... #MSK #rheumatology ... #diagnosis #arthritis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
if WBC > 5 or elevated ... effusions, weight gain ... : >3 symptoms, or ... Moderate > 2/3 and ... initiation • Differential
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... • Progressive symptoms ... or proteinase 3 ... Eosinophilia, asthma, chronic ... #Diagnosis #Rheumatology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... very remarkable w/differential ... claudication: pain ... them, but urgent rheumatology ... #Symptoms #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
or proteinase 3 ... Eosinophilia, asthma, chronic ... Presentation - Systemic Symptoms ... purpura: strong sign ... #diagnosis #rheumatology