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diagnosis differential rheumatology nephrology pulmonary ana anca antibodies antibody antinuclear blood causes classification diseases management prs syndromes treatment urine urology
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... urine sediment by microscopy ... syndrome: • ... : - RBC casts ... Diagnostic of GN or vasculitis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... • Sjögren syndrome ... : • Microscopic ... vasculitis - MPO
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Dyspnea, Fever, Hematuria ... ANCA-positive vasculitis ... polyangiitis, Microscopic ... ANCA-negative vasculitis ... IgA-associated vasculitis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... polyangiitis), MPA (microscopic ... FINDINGS: • U/A: microscopic ... or gross hematuria ... , RBC casts, low
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
multiplex • Hematuria ... pulmonary and renal ... PR3-ANCA): • Microscopic ... Dx: GPA, EGPA, microscopic ... • Urinalysis (Renal
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Mononeuritis multiplex • Hematuria ... pulmonary and renal ... (PR3-ANCA)): Microscopic ... • Behcet syndrome ... • Cogan syndrome
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