ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA (in 70% of cases) 2. Anti-Sm (Smith) 3. Anti-histone (in drug-induced SLE) • Systemic sclerosis (scleroderma) - Anti-Scl-70 (anti-topoisomerase antibody) seen in 30—70% of cases • Sjögren syndrome 1. Anti-Ro/SSA 2. Anti-La/SSB • Polymyositis and dermatomyositis 1. Anti-JO1 2. Anti-Mi2 • Mixed connective tissue disease - Anti-U1-RNP ANCA-Associated Vasculitis: • Microscopic polyangiitis - MPO>PR3 - ANCA+ 90% • Granulomatosis with polyangiitis - PR3 (80-90%) > MPO - ANCA+ 90% • Granulomatosis with polyangiitis without renal involvement - PR3>MPO - ANCA+ 60% • Eosinophilic granulomatosis with Polyangiitis (Churg-Strauss) - MPO>PR3 - ANCA+ 30-60% • Renal-limited vasculitis - MPO: 75-80% - ANCA+ 90% • Anti-GBM disease - MPO>PR3 - ANCA+ 10-40% Dr. Jorge Cortés @Jcortesizaguirr #ANA #Antinuclear #Antibody #ANCA #Antineutrophil #antibodies #diagnosis #rheumatology #diseases
