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diagnosis differential nephrology rheumatology pulmonary urine ana anca antibodies antibody antineutrophil antinuclear blood bloodsmear borrelia causes classification clinical fever hematuria
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
Atlas of Urine Microscopy ... fresh at time of microscopy ... renal disease ... contamination #Urine #Microscopy ... #Atlas #key #diagnosis
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
basement membrane disease ... - Alport syndrome ... hematuria: - RBC casts ... Diagnostic of GN or vasculitis ... of glomerular disease
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... ANCA-positive vasculitis ... polyangiitis, Microscopic ... ANCA-negative vasculitis ... IgA-associated vasculitis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... • Sjögren syndrome ... : • Microscopic ... vasculitis - MPO
Urinary Casts and Disease Associations Hyaline - May be nonspecific; seen in normal individuals or during severe
Disease Associations ... Advanced kidney disease ... tubulointerstitial nephritis, renal ... Fatty - Nephrotic syndrome ... #Differential #Microscopy
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... PR3-ANCA): • Microscopic ... • Cogan Syndrome ... Dx: GPA, EGPA, microscopic ... • Urinalysis (Renal
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... polyangiitis), MPA (microscopic ... life-threatening diseases ... FINDINGS: • U/A: microscopic ... hematuria, RBC casts
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... Mucocutaneous lymph node syndrome ... (PR3-ANCA)): Microscopic ... • Behcet syndrome ... • Cogan syndrome
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
resolved after 2-3d ... Several cases have ... Syndrome: 3d of ... Infectious Diseases ... recurrentis #BloodSmear #microscopy
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
region Viral Syndromes ... thrombocytopenia, and renal ... falciparum: Most cases ... tests of liver and renal ... dipstick test, microscopic
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