6 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Renal Syndromes ... ANCA-positive vasculitis ... polyangiitis, Microscopic ... #Renal #Syndrome
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
urine sediment Microscopic ... urine sediment by microscopy ... pain hematuria syndrome ... hematuria: - RBC casts ... Diagnostic of GN or vasculitis
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... polyangiitis), MPA (microscopic ... Renal Syndromes ... hematuria, RBC casts ... #Renal #Syndromes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... • Sjögren syndrome ... : • Microscopic ... vasculitis - MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
and renal abnormalities ... PR3-ANCA): • Microscopic ... • Cogan Syndrome ... Dx: GPA, EGPA, microscopic ... • Urinalysis (Renal
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
and renal abnormalities ... Mucocutaneous lymph node syndrome ... (PR3-ANCA)): Microscopic ... • Behcet syndrome ... • Cogan syndrome