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diagnosis management hematology ammonia biliary cholangitis cirrhosis differentiation encephalopathy hyperammonemia leukostasis lysis neurology oncology pbc posterior pres primary reversible tls
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... initiation • Differential ... #management #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... limb ischemia, bowel ... : • Pathophysiology ... diagnosis #management #hematology
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
myeloma, CML, AML ... rare): - Reye syndrome ... (Peds) - Primary ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
• Female:Male 9: ... 65 years PBC Pathophysiology ... PBC Signs and Symptoms ... bile ducts Differential ... diagnosis #workup #hepatology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Encephalopathy Syndrome ... Etiology: • Pathophysiology ... Neurological symptoms ... Reversible course Differential ... Seizures: Treat with AEDs
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