6 results
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Systemic Lupus (SLE) General ... disease (30%): ... haemolytic Coombs positive ... SLE #systemic #erythematosus ... #signs #symptoms
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
laboratory findings (ANA ... , and elevated serum ... APLA/LAC: • Renal ... artery or vein ... thrombosis • Pelvic vein
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
(panuveitis, retinal ... also involved), Venous ... Skin lesions • Positive ... Glucocorticoids 5-ASA ... diagnosis #management #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
gastrointestinal, and/or central ... nervous system ... systemic lupus erythematosus ... purpura: strong sign ... LFT • ESR • ANA
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
pulmonary and renal ... purpura: Strong sign ... ischemia • Skin: Erythematous ... Angiitis of the Central ... gastrointestinal, and/or central
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... NXP-2 antibody positive ... had more severe disease ... levels of: • Serum ... • Clear cell renal