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management rheumatology dermatology differential pruritus systemic causes generalized syndrome acromegaly activation acute chronic cirrhosis endocrinology erythematosus failure gastroenterology hemeonc hemodialysis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Clinical Guidelines ... in those with CLD ... months without treatment ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... Algorithm - Systemic ... • Cholestatic liver ... renal failure/uremia ... Pruritus #primary #secondary
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... leakage of RBC's secondary ... deficiency • Liver ... #hematology #rheumatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Algorithm Blood ... renal failure/uremia ... #Pruritus #secondary ... #generalized #dermatology
Management of Pruritus in Patients with Chronic Kidney Disease Pruritus with no primary lesions - differential diagnosis:
- differential diagnosis ... pruritus • Liver ... pruritus • Hematologic ... #Pruritus #Treatment ... #Algorithm #Hemodialysis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... Fever is the main clinical ... thrombocytopenia • Liver ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
GrepMed Handbook Clinical ... , hair growth, skin ... Acromegaly occurs secondary ... GH stimulates liver ... Endocrinology #Treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... erythematosus (ACLE ... Differential Diagnosis ... Malignancy (e.g. hematologic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
other diseases • Secondary ... salivary ducts Clinical ... vasculitis: 10%-16% Liver ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
STX11, STXBP2 • Secondary ... Clinical Presentation ... - Cytopenias (anemia ... - Elevated liver ... #Management #Hematology
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