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diagnosis hepatology lfts alkaline biliary chemistry cholangitis cirrhosis drug elevation fatty gastroenterology hepatitis idiosyncratic induced interpretation liverenzymes obgyn obstetrics pathophysiology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Vascular Causes ... • Iatrogenic: DILI ... GGT/5-NT: ↑ - ALP ... hemolysis) • ALP
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
phos/ULN ALP) ... • Liver injury ... disease • If ALP ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... ALP: - Enzymes ... - Increased ALP ... Intestine - Other causes ... #Phosphatase #ALP
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... = nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... iMedEducation #AFLP
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Diagnosis Algorithm ... • Pregnancy - AFLP ... #Causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... asymptomatic • Pruritus ... obstruction • ALP ... or higher • Liver ... bile ducts Differential
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