Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent injury (ie, acetaminophen/APAP) • Idiosyncratic - less common, only affects susceptible individuals, less consistent dose relationship, varied presentation • Chronic - ongoing ↑ LFTs or symptoms of liver disease 6-9 mo after DILI onset Calculate R-Value • Hepatocellular or Mixed DILI • Cholestatic DILI By Tina Hang, MD @TinaPhamHang via @EmoryGastroHep #DILI #Drug #induced #Liver #Injury #Idiosyncratic #differential #Diagnosis #Management #gastroenterology #algorithm #gastroenterology #hepatology
