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diagnosis management criticalcare differential druginduced oncology rheumatology anticoagulation antiphospholipid aps cardiology clinical comparison dil emergencies fever fuo guidelines hematology hemeonc
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE ... • Immunologic Workup ... constitutional symptoms • Treatment ... • Immunologic Workup ... life-threatening • Treatment
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... from antibodies formed ... ): • Lupus anticoagulant ... Anticardiolipin antibodies (aCL ... to be present Treatment
Possible Algorithm for Workup of Fever of Unknown Origin (FUO) Tier 1 Workup: • CBC, comprehensive metabolic
Possible Algorithm ... Consider: CK, ANCA ... cryoglobulin, serum ACE ... Neuroimaging • Echocardiogram ... DrEricStrong #FUO #Algorithm
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... mononeuritis multiplex WORKUP ... Auto-antibodies: ANCA ... o infection • Echocardiogram ... diagnosis #management #treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
that are poorly formed ... or don’t work properly ... factor (GCSF) treatments ... Workup: • Complete ... marrow studies Treatment
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... lupus cases, drug-dependent ... • Immunologic Workup ... constitutional symptoms • Treatment ... rheumatology #diagnosis #treatment
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
carry treatment ... hormones that work ... for Refeeding Syndrome ... #differential #algorithm ... #criticalcare #foamed
Perhaps quite too often, the knee-jerk reaction to an elevated Troponin is to call our friends
“one size fits all ... #diagnosis #algorithm ... #cardiology #echocardiogram ... #criticalcare #foamed ... #treatment
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
fever: - Fever + ANC ... full infectious work-up ... days → add fungal work-up ... afebrile 24-48 h and ANC ... (~20 %) and APL
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