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rheumatology management differential myositis abnormal algorithm enzymes erythematosus gap globulin gout hepatology leukostasis lfts liver lupus lysis myopathy polychondritis protein
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... , holster sign, ... anti-synthetase syndrome ... after 2 years of treatment ... #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
have fever - ACS ... WBC >100k, + lab signs ... organ damage • Treatment ... #TLS #diagnosis ... #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... Differential Diagnosis ... disease • Non-autoimmune ... Malignancy (e.g. hematologic ... deficiencies • Autoimmune
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Diagnosis: • Dry ... Nephrogenic DI Hematologic ... MALT Lymphoma • Lung ... Adenocarcinoma Treatment
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
clinical symptoms/signs ... box indicates all ... presence of metabolic syndrome ... mellitus; USS, ultrasound ... Abnormal #Algorithm #Hepatology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
sex • Metabolic syndrome ... not possible • Ultrasound ... double contour sign ... +Radiographic signs ... #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... myopathies Diagnostic ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Cirrhosis, ETOH, autoimmune ... ovarian tumors, lung ... #differential #diagnosis ... #hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cartilage in the body (Autoimmune ... Males • Affects all ... /EGPA • RA Diagnosis ... affected tissue Treatment ... #diagnosis #management
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