9 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Anticoagulant Sites of Action ... #Medications #Pharmacology ... #Pathophysiology ... #Mechanisms #DOAC ... #Hematology
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
: Mechanism of Action ... #Lactulose #pharmacology ... mechanism #ammonia #hepatology ... #pathophysiology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... binding to its active ... #Pharmacology #Pathophysiology ... Heparins #LMWH #UFH #DOAC ... #Fondaparinux #NOAC
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
, Intermediate Action ... Blockade, Fast Action ... Blockade, Slow Action ... Vaughan #Williams #Pharmacology ... #pathophysiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... , Intermediate Action ... Blockade, Fast Action ... Antiarrhythmics #Pharmacology ... #pathophysiology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... intracellular calcium causes ... CaitEKulig #Digoxin #Pharmacology ... #Pathophysiology
Oral Antibiotics for Acne - Indicated for Moderate-to-Severe Acne 
First-Line Drug Class: Tetracyclines 

In the last
First-Line Drug Class ... The newest option ... #Antibiotics #Pharmacology ... #Management #Dermatology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
rare with ~100 cases ... gravis [use with caution ... Benefits #Lupus #pharmacology ... #sideeffects #rheumatology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
anemia (MAHA) Pathophysiology ... Initiate ACEi (short-acting ... • Refractory cases ... Renal #Crisis #rheumatology