12 results
Biologic therapy for eosinophilic asthma 
• Mepolizumab (Nucala) 
  • Anti-lL-5, 100 mg SQ q4
asthma • Mepolizumab ... q4 weeks • Peripheral ... q4 weeks • Peripheral ... q8 weeks • Peripheral ... #asthma #Biologic
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... 45yo, F; Hx of asthma ... SOB, sinusitis, wheezing ... Weeks) - Hx of asthma ... food hx; Fever, wheezing
Eosinophilic Pneumonia
When to suspect Eosinophilic Pneumonia? Non-resolving pneumonia + BAL > 25% eosinophils + excluded more
Eosinophilic Pneumonia ... Effusions - Rare Peripheral ... tobacco hx, >60% asthma ... Constitutional Symptoms - Peripheral ... edema" - Common Peripheral
First-line therapies for Asthma, Asthma-COPD Overlap and COPD

The diagnosis of COPD, asthma, and ACO initially requires
therapies for Asthma ... , Asthma-COPD Overlap ... , and ACO initially ... analysis with eosinophil ... ACO = asthma-COPD
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... Primary Eosinophilia ... Secondary Eosinophilia ... histiocytosis • Allergic: Asthma ... , ABPA), Gleich
On the left we see a chest film with a typical finger-in-glove shadow.
The HRCT shows focal
clinical setting (asthma ... and serum eosinophilia ... aspergillosis (ABPA ... #CXR #CTChest #ABPA
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... FOR TESTING: • Peripheral ... blood eosinophilia ... specific symptoms • Eosinophilia ... common causes are asthma
The infant with tachypnea or wheeze - Clinical Conditions to Consider
 - Bronchiolitis 
 - Pneumonia
Transient early wheezing ... - Non-atopic wheezing ... infection - Atopic asthma ... — recurrent wheezing ... #Diagnosis #Peds
Causes of Pediatric Wheezing - Differential Diagnosis Algorithm
CXR Abnormal:
 • Pulmonary Sequestration
 • Congenital Adenoid Cystic
Causes of Pediatric Wheezing ... Beta-Agonist: • Asthma ... Structural Anomaly #Wheezing ... Algorithm #Causes #Peds
Allergic Bronchopulmonary Aspergillosis (ABPA)
WHAT IS IT?
Hypersensitivity response to Aspergillus fumigatus in the airways
 • Primarily affects
Aspergillosis (ABPA ... with underlying asthma ... • Wheezing • Increased ... Aspergillus • Peripheral ... eosinophilia and