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diagnosis causes coagulation differential management prolonged pt algorithm anemia aplastic dic disseminated intravascular mds microangiopathy myelodysplasia myelodysplastic syndromes thrombotic tma
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
TMA: Unexplained thrombocytopenia ... hemoglobin/hemosiderin, Hepatic ... hemosiderin • PT/aPTT ... normal • DAT ... Management #Algorithm #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... 100mg/dL) - Heparin ... INR < 2.3 - APTT ... < 1.5 x normal ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... Reduced liver synthesis ... Jcortesizaguirr #Abnormal ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... deficiency • Reduced ... amyloidosis #Abnormal ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... syndrome (MDS) (normal ... cells is much reduced ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... IDUS) • Immune Thrombocytopenia ... unclassifiable: Reduced ... Syndromes #diagnosis #hematology ... #oncology
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