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diagnosis hematology management differential intravascular product coagulation dermatology dic extravascular hemolysis hemolytic nonpalpable palpable rheumatology thromboticthrombocytopenicpurpura transfusion transfusions treatment ttp
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ): - Disseminated ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... #anemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... : - Thrombocytopenia ... - Hemolytic anemia ... fever • Drug reactions ... Differential #Diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... ABO incompatible blood ... Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... Treat primary cause
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Post Transfusion Purpura ... Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Post Transfusion Purpura ... Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... more likely to cause
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... Purpura Activity ... result in severe anemia ... of Peripheral blood ... immune hemolytic anemia
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