18 results
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
and Bilirubin Metabolism ... insult Bilirubin metabolism ... #ASTALT #AlkPhos ... Bilirubin #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... cycle found in the liver ... concentrations > 5 μg/mL ... Diagnosis of MALA ... Toxicity #Toxicology #Diagnosis
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... locations: Wrist, MCP ... culture used to diagnose ... • Male sex • Metabolic ... syndrome • Medications
Approach to Elevated Bicarbonate (HCO3)
Risk Factors for Hypercapnea? (Hx of COPD, OSA, sedative use, CNS/muscular disorders?)
(+)
(Hx of COPD, OSA ... Gas) (-) Likely Metabolic ... Contraction Urine Cl ... Barter, or Gitelman Syndrome ... alkalosis #algorithm #diagnosis
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... autosomal recessive salt-losing ... → Hypokalemia Metabolic ... #Pathophysiology ... #nephrology #diagnosis
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Refeeding Syndrome ... glucose, fluid, salt ... • Incr Glucose Metabolism ... - Metabolic ... #diagnosis #pathophysiology
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
decompensated liver ... and decreased metabolism ... rare): - Reye syndrome ... deficiency #Ammonia #Pathophysiology ... #Differential #Diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... vein: Budd-chiari syndrome ... • Metabolic/Hereditary ... be abnormal AST ... • Gilbert's syndrome
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
(AG) = {Na - (Cl ... - Differential Diagnosis ... D-lactate (short bowel syndrome ... lung disease (COPD ... Interpretation #Diagnosis
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
resistance • Metabolic ... disequilibrium syndrome ... • Diagnosis of ... Inhibitors of Na+K+2Cl ... heart failure, liver