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Acute Mountain Sickness Low partial pressure of oxygen at high altitude • Stop ascent • Supportive
oxygen at high altitude ... • Stop ascent ... Diagnosis #Management #Altitude
Acute Mountain Sickness - High Altitude Incidence varies - rate increases with altitude and rate of ascent
Sickness - High Altitude ... increases with altitude ... and rate of ascent ... seen with rate of ascent ... 1) No further ascent
HIGH ALTITUDE PULMONARY EDEMA (HAPE) • High altitude disease that kill most people • Incidence: severe
HIGH ALTITUDE PULMONARY ... (HAPE) • High altitude ... recurrence 1) Slower ascent ... Bloodman #High #Altitude
The Evidence for Aspirin - Visual Abstract Three new aspirin trials in three different populations: -
Moderate Risk (ASCVD ... Increased bleeding ASCEND ... VisualAbstract #ARRIVE #ASCEND
Medications for High-Altitude Sickness Acetazolarnide • Carbonic Anydrase Inhibitor Bicarb diuresis & metabolic Acidosis ->
Medications for High-Altitude ... #HighAltitude #Altitude
Differential Diagnosis: Cyanosis - Mnemonic "COLD PALMS" Peripheral cyanosis • Cold • Obstruction • LVF and shock
Polycythemia • Altitude
Oxygen-Hemoglobin Dissociation Curve Left Shift (↓ O2 unloading to tissue), Left = Lower: • ↓ H+ (↑
2,3-BPG • High Altitude
Diabetes Type 2 Medication Management and Titration Algorithm - First line therapy is metformin and comprehensive lifestyle
- Established ASCVD ... Without established ASCVD
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD EMPA-REG OUTCOME - Empagliflozin lowered CV events
events in T2DM + ASCVD ... events in T2DM + ASCVD ... or ASCVD risk; ... MACE, in T2DM + ASCVD ... or ASCVD risk.
Mesenteric Ischemia - Differential Diagnostic Schema Chronic: ASCVD, Venous, Vasculitides 5% (PAN, [E]GPA, IgA, MPA) Acute - Venous
Schema Chronic: ASCVD ... hypo-/akinesis), ASCVD ... failure, Dissection, ASCVD
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