8 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Cryoglobulinemia, Endocarditis ... Pauci-immune mediated (Negative ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
• Coagulase-negative ... Septic Emboli Cause ... Marantic (NTBE) Differential ... Paradoxical emboli via ASD ... Treat underlying cause
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... more likely to cause ... RBCs (stored at 4C ... diagnosis #management #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... more likely to cause ... RBCs (stored at 4C ... diagnosis #management #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... decrease in most cases ... antiglobulin tests - Negative ... WBC count and differential ... Diagnosis #Workup #Hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... weeks) Can Be Caused ... • Bacterial endocarditis ... aureus • Gram-negative ... #Joint #pain #Differential
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
and Differential ... aureus, Coagulase-negative ... Septic emboli cause ... Treat underlying cause ... #Differential #
Pyogenic liver abscess in children
Common bacterial causes in children:
 • S.aureus
 • Strep spp
 • Enteric
Common bacterial causes ... • Enteric gram negative ... artery (e.g., endocarditis ... in those with concurrent ... children #peds #differential