8 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Cryoglobulinemia, Endocarditis ... Pauci-immune mediated (Negative ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... and Differential ... hypertension despite concurrent ... patients with a negative ... #causes #Differential
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... microbiological techniques Work-up ... but important causes ... #Infective #Endocarditis ... #diagnosis #differential
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
• Coagulase-negative ... Septic Emboli Cause ... Marantic (NTBE) Differential ... Paradoxical emboli via ASD ... Treat underlying cause
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... antiglobulin tests - Negative ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
and Differential ... aureus, Coagulase-negative ... Septic emboli cause ... Treat underlying cause ... #Differential #
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... weeks) Can Be Caused ... • Bacterial endocarditis ... aureus • Gram-negative ... #Joint #pain #Differential
Pyogenic liver abscess in children
Common bacterial causes in children:
 • S.aureus
 • Strep spp
 • Enteric
Common bacterial causes ... • Enteric gram negative ... artery (e.g., endocarditis ... in those with concurrent ... children #peds #differential