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alkalosis causes metabolic pathophysiology syndrome algorithm chloride defects epithelial hyperreflexia hypokalemia hyporeflexia inherited kidney management testing tubule urinary urine
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
thiazide-sensitive sodium-chloride ... in the distal tubule ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology ... #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
ascending limb Gitelman ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia Focal Hyporeflexia: • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Polyneuropathy, Acute ... stroke, Acute spinal ... Testing #Causes #differential ... #diagnosis #table ... #neurology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... distal convoluted tubule ... ratio 0.5%) Differential ... #Syndrome #diagnosis ... #nephrology #management
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Bartter syndrome, Gitelman ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential # ... diagnosis
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
Metabolic Alkalosis: Differential ... Diagnosis ECF ... postchronic hypercapnia (acute ... furosemide-like lesion) • Gitelman ... #nephrology
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