Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter syndrome - Na-K-2Cl cotransporter, K channel, Cl channel, or barrtin (recruits Cl channel to basolateral membrane) in thick ascending limb Gitelman syndrome - Thiazide-sensitive Na—Cl cotransporter in distal convoluted tubule Liddle syndrome - Increased open time and number of principal cell epithelial sodium channels Pseudohypoaldosteronism - Decreased activity of epithelial sodium channels or defective mineralocorticoid receptor Distal renal tubular acidosis - alpha-Intercalated cell Cl-/HCO3- exchanger,H+-ATPase Nephrogenic diabetes insipidus - Vasopressin-2 (V2) receptor or aquaporin-2 deficiency Nephrogenic syndrome of inappropriate antidiuresis - Increased vasopressin-2 (V2) receptor activity #Tubule #Epithelial #Inherited #Defects #Kidney #Nephrology #Diagnosis #Differential #Table
