10 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
in the distal tubule ... → Hypokalemia Metabolic ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology ... #diagnosis
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic ... autosomal dominant kidney ... of echogenic kidneys ... #Workup #nephrology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
ABG And BMP Normal ... Diagnosis: Causes ... sedation, narcotics, CVA ... #Summary #Nephrology ... #ABG #bloodgas
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Bartter syndrome, Gitelman ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential # ... diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects in Kidney ... ascending limb Gitelman ... Inherited #Defects #Kidney ... #Nephrology #Diagnosis ... #Differential #
Normal Anion-Gap Acidosis (NAGMA) - Differential Diagnosis Framework and Workup

NAGMA
- Chem, ABG or VBG
- Calculate Anion
Diagnosis Framework ... - Chem, ABG or ... NonAnionGap #Acidosis #Metabolic ... #Diagnosis #Workup ... #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Hypochloremia - Differential ... Diagnosis Algorithm ... - Bartter - Gitelman ... unloading • Kidney ... Pathophysiology #Nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
differentiating kidney ... Bartter syndrome, Gitelman ... #Hypokalemia #diagnosis ... #Algorithm #differential ... #potassium #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Alkalosis: Differential ... Diagnosis ECF ... furosemide-like lesion) • Gitelman ... #Diagnosis #Causes ... #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... Hypochloremic metabolic ... ratio 0.5%) Differential ... #Syndrome #diagnosis ... #nephrology #management