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differential algorithm pathophysiology syndrome chloride hypokalemia hypophosphatemia checklist framework hypochloremia ischemic management metabolic phosphate phosphorus potassium stroke urinary urine
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
in the distal tubule ... Hypokalemia Metabolic alkalosis ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology ... #diagnosis
Gitelman Syndrome - Diagnosis and Workup Blood Work: - Hypokalemia - Hypomagnesemia - Metabolic Alkalosis - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic Alkalosis ... autosomal dominant kidney ... of echogenic kidneys ... #Workup #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
• Normal/low ... Bartter syndrome, Gitelman ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential #diagnosis
Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Appropriately Low ... Kidney Phosphate ... Acute Respiratory Alkalosis ... #Algorithm #nephrology ... #phosphorus #workup
How do you work up an ischemic CVA? A) Initial Evaluation • ABCs • IV access, monitor
How do you work ... suspicion) • +/- bubble ... #stroke #workup ... #diagnosis #checklist ... #neurology
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... - Differential Diagnosis ... Glucose, Acute resp. alkalosis ... Fanconi syndrome, CA ... #phosphate #nephrology
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
differentiating kidney ... - Metabolic Alkalosis ... Bartter syndrome, Gitelman ... #Hypokalemia #diagnosis ... differential #potassium #nephrology
Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W
- Differential Diagnosis ... Decreased Intake: • Low ... - Bartter - Gitelman ... unloading • Kidney ... Pathophysiology #Nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
distal convoluted tubule ... • Normal or low ... Hypochloremic metabolic alkalosis ... #Syndrome #diagnosis ... #nephrology #management
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