11 results
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome
 • Urine Chloride
 • Urine Ca/Cr ratio

Dr. Krithika
syndrome • Urine ... Chloride • Urine ... Ca/Cr ratio ... #Algorithm #nephrology ... #hypokalemia #diagnosis
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
↑ Aldosterone: Kidney ... Mg2+ deficiency, Bartter ... syndrome, Gitelman ... differential #algorithm #diagnosis ... #nephrology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... : - Hypokalemia ... Elevated Renin Urine ... of echogenic kidneys ... #Workup #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... Hypocalciuria (spot urine ... syndrome • Pseudo Bartter-Gitelman ... #Syndrome #diagnosis ... #nephrology #management
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
differentiating kidney ... Emesis, Diuretics, Bartter ... syndrome, Gitelman ... #diagnosis #Algorithm ... differential #potassium #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
in the distal tubule ... H+ secretion → Hypokalemia ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology ... #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects in Kidney ... acid transporter Bartter ... ascending limb Gitelman ... Inherited #Defects #Kidney ... #Nephrology #Diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter ... syndrome, Gitelman ... in the proximal tubule ... #Algorithm #nephrology ... #differential #diagnosis
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
Approach to Acute Kidney ... require urgent nephrology ... common culprits: Hypovolemia ... IMPROVEMENT If the urine ... #diagnosis #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... actively working • Bartter ... furosemide-like lesion) • Gitelman ... #Differential #Diagnosis ... #Causes #nephrology