12 results
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Urine K+ <13 mEq ... ↑ Aldosterone: Kidney ... Bartter syndrome, Gitelman ... #algorithm #diagnosis ... #nephrology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Elevated Renin Urine ... Inappropriate renal K+ ... of echogenic kidneys ... #Workup #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
differentiating kidney ... A urine K/Cr ratio ... Bartter syndrome, Gitelman ... #Hypokalemia #diagnosis ... #nephrology #low
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
in the distal tubule ... nephron → - ↑ K+ ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology ... #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects in Kidney ... syndrome - Na-K- ... cotransporter, K ... ascending limb Gitelman ... #Nephrology #Diagnosis
Normal Anion-Gap Acidosis (NAGMA) - Differential Diagnosis Framework and Workup

NAGMA
- Chem, ABG or VBG
- Calculate Anion
- Differential Diagnosis ... Framework and Workup ... 5.5 • Serum K ... #Differential #Diagnosis ... #Workup #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Bartter syndrome, Gitelman ... in the proximal tubule ... of sodium and potassium ... #Algorithm #nephrology ... #differential #diagnosis
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
- Differential Diagnosis ... Framework Rule ... leukemia Measure Urine ... #Framework #Workup ... #phosphate #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... furosemide-like lesion) • Gitelman ... other • Severe potassium ... #Differential #Diagnosis ... #Causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... Hypocalciuria (spot urine ... Supplement: • Potassium ... #Syndrome #diagnosis ... #nephrology #management