13 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Syndrome: Proximal tubule ... Bartter Syndrome ... Distal convoluted tubule ... Syndrome: Collecting tubule ... Pathophysiology #Nephrology
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome
 • Urine Chloride
 • Urine Ca/Cr ratio

Dr. Krithika
Differentiating Gitelman ... syndrome from Bartter ... Chloride • Urine Ca ... #Algorithm #nephrology ... #hypokalemia #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Defects in Kidney Tubule ... acid transporter Bartter ... distal convoluted tubule ... receptor activity #Tubule ... Defects #Kidney #Nephrology
How do you work up an ischemic CVA?
A) Initial Evaluation
 • ABCs
 • IV access, monitor
How do you work ... hemorrhage and other mimics ... suspicion) • +/- bubble ... #diagnosis #checklist ... #neurology
What are common stroke mimics?
From Konrad CN, Crocco T, Biola J, Larrabee H. Is it stroke,
common stroke mimics ... #Diagnosis #Differential ... #Stroke #Mimics ... #Table #CVA #Incidence ... #Misdiagnosed #Neurology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... in the distal tubule ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology ... #diagnosis
Pronator Drift Testing for Stroke
Subtle extensor weakness - Sign of Upper motor neuron lesion
In detecting CT/MRI
Testing for Stroke Subtle ... #physicalexam #diagnosis ... #neurology #cva
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
distal convoluted tubule ... syndrome, Renal tubular ... syndrome • Pseudo Bartter-Gitelman ... #Syndrome #diagnosis ... #nephrology #management
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
diuretics after renal tubule ... indicates a renal tubule ... actively working • Bartter ... furosemide-like lesion) • Gitelman ... #Causes #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter ... syndrome, Gitelman ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential #diagnosis