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differential metabolic pathophysiology abg acidbase algorithm base bloodgas causes chloride defects disorders epithelial framework gas hypokalemia hypophosphatemia inherited interpretation kidney
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... in the distal tubule ... Hypokalemia Metabolic alkalosis ... Contraction → ↑ Renin ↑ Ca ... #nephrology #diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
, Gitelman syndrome ... in the proximal tubule ... and potassium acid ... urine #Algorithm #nephrology ... #differential #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
Cystinuria - Amino acid ... ascending limb Gitelman ... Liddle syndrome ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Gitelman Syndrome - Diagnosis and Workup Blood Work: - Hypokalemia - Hypomagnesemia - Metabolic Alkalosis - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic Alkalosis ... dr_missyhanna #Gitelman ... #Syndrome #Diagnosis ... #Workup #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
: Differential Diagnosis ... indicates a renal tubule ... furosemide-like lesion) • Gitelman ... #Differential #Diagnosis ... #Causes #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... - Differential Diagnosis ... Glucose, Acute resp. alkalosis ... , CA Inh., Osmotic ... #phosphate #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... distal convoluted tubule ... Hypochloremic metabolic alkalosis ... #Syndrome #diagnosis ... #nephrology #management
Acid Base Disorders - Blood Gas Interpretation Steps for Blood Gas Interpretation: 1. Acidemia or Alkalemia? 2.
Acid Base Disorders ... D-lactate (short bowel syndrome ... sedation, narcotics, CVA ... #Summary #Nephrology ... ABG #bloodgas #Acid
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