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differential algorithm alkalosis hypokalemia metabolic pathophysiology bartter causes checklist chloride clinical defects epithelial framework half hypophosphatemia inherited ischemic kidney management
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome • Urine Chloride • Urine Ca/Cr ratio Dr. Krithika
Differentiating Gitelman ... Chloride • Urine Ca ... krithicism #Gitelman ... #Algorithm #nephrology ... #hypokalemia #diagnosis
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Syndrome is a rare ... in the distal tubule ... Contraction → ↑ Renin ↑ Ca ... #nephrology #diagnosis
How do you work up an ischemic CVA? A) Initial Evaluation • ABCs • IV access, monitor
How do you work ... suspicion) • +/- bubble ... #stroke #workup ... #diagnosis #checklist ... #neurology
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
transporter Bartter syndrome ... ascending limb Gitelman ... Liddle syndrome ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Gitelman Syndrome - Diagnosis and Workup Blood Work: - Hypokalemia - Hypomagnesemia - Metabolic Alkalosis - Elevated
Gitelman Syndrome ... Workup Blood Work ... dr_missyhanna #Gitelman ... #Syndrome #Diagnosis ... #Workup #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... - Differential Diagnosis ... , CA Inh., Osmotic ... #Framework #Workup ... #phosphate #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
: Differential Diagnosis ... indicates a renal tubule ... furosemide-like lesion) • Gitelman ... #Differential #Diagnosis ... #Causes #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... distal convoluted tubule ... #Syndrome #diagnosis ... #nephrology #management
One and a Half Syndrome on Physical Exam This 28 year old patient presented to clinic with
One and a Half Syndrome ... Entering VA was ... An APD was noted ... the hospital, diagnosed ... ophthalmology #neurology
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 Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
diuretic use, Bartter syndrome ... , Gitelman syndrome ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential #diagnosis
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