9 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... Hypokalemia Metabolic alkalosis ... #Syndrome #Pathophysiology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... weakness and #Acute ... #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... postchronic hypercapnia (acute ... furosemide-like lesion) • Gitelman ... #Differential # ... Diagnosis #Causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... distal convoluted tubule ... ratio 0.5%) Differential ... #nephrology #management ... #pathophysiology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... clinical context and signs ... • Cardio-renal syndrome ... cardiac imaging #Acute ... #Kidney #Injury
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter syndrome ... , Gitelman syndrome ... in the proximal tubule ... urine #Algorithm #nephrology ... #differential #
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
hypertension and signs ... kidney injury). ... and metabolic alkalosis ... renal bruit or signs ... Neurologic disorders
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... diuretic use), Gitelman's ... Hypomagnesemia, Acute ... Hypokalemia #Causes #differential ... #diagnosis #nephrology
The Neurological Evaluation of a Comatose Patient

Definition:
 • Coma: a state of unresponsiveness; the absence of
consciousness Differential ... • Mutism Pathophysiology ... : • Severe injury ... • Examine for signs ... #PhysicalExam #neurology