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diagnosis nephrology differential management algorithm alkalosis chloride metabolic cerebritis cns defects disease erythematosus fanconi hypochloremia hypokalemia liddle localization lupus nephron
Localization of Renal Tubular Defects Fanconi Syndrome: Proximal tubule Bartter Syndrome: Thick ascending loop of Henle Gitelman Syndrome: Distal
Bartter Syndrome ... loop of Henle Gitelman ... #Fanconi #Bartter ... Nephron #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... distal convoluted tubule ... • Bartter syndrome ... • Pseudo Bartter-Gitelman ... #pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
Causes of Metabolic ... actively working • Bartter ... furosemide-like lesion) • Gitelman ... Differential #Diagnosis #Causes ... #nephrology
Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W
- Diuresis - Bartter ... - Gitelman ... SIGNS: • Muscle ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... periventricular white matter ... azathioprine #Behcet ... #management #signs ... #symptoms #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... or blood-brain barrier ... #rheumatology #
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
diuretic use, Bartter ... syndrome, Gitelman ... syndrome, Hypomagnesemia ... in the proximal tubule ... the indicated causes
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... affects the skin, neurologic ... tract, and often causes ... vasculitis • Behcet ... Differential #Diagnosis #Rheumatology
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