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Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Chemistry Tests - AST ... , ALT, Alkaline ... Bilirubin Metabolism AST ... and ALT: • AST ... liver, 80% of AST
Standardized Physical Abuse Guideline <6 months of age • Social work consult • Skeletal survey • Head
survey • Head CT, AST ... , ALT, lipase ... Abdominal CT if AST ... months of age if AST ... or ALT> 80, signs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Hepatocellular Level • AST ... to liver than AST ... elevated ALP • AST ... NT: ↑ • ALP > AST ... • Near normal AST
Features of Components of Liver Function Tests #Diagnosis #IM #GI #LFTs #Liver #Function #Tests #Locations #AlkPhos
Locations #AlkPhos #AST ... #ALT #Ddxof
Gestational Hypertension & Preeclampsia Gestational Hypertension (gHTN) • BP > 140/90 • Onset > 20 wks gestation
Thrombocytopenia • Elevated AST ... /ALT • Pulmonary ... Thrombocytopenia • Elevated AST ... /ALT • Hemolysis
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
of jaundice • AST ... >50, AST/ALT >1.5 ... laboratory tests (e.g., AST ... or >400 IU/L, AST ... /ALT <1.5), ANA
Liver Function Tests (LFTs) - Aspartate aminotransferase (AST) - Alanine aminotransferase (ALT) - Alkaline
aminotransferase (AST ... aminotransferase (ALT
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
of jaundice - AST ... >50, AST/ALT >1.5 ... laboratory tests (e.g., AST ... or >400 IU/L, AST ... /ALT <1.5), ANA
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
or AST > ALP): ... • Severe - ALT ... • Moderate - ALT ... Pattern (ALP > ALT ... or AST): • US
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
to liver than AST ... elevated ALP • AST ... bilirubin: ↑ • AST ... NT: ↑ - ALP > AST ... hematoma) • AST
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