5099 results
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Hepatitis (eg Viral) Management ... immunosuppressive tx: - ALT ... + AST > 10x ULN ... - ALT + AST > ... AIH #Diagnosis #Management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... CPK 5X ULN • AST ... /ALT Elevation 4 ... :1 ratio (AST declines ... Differential #Diagnosis #Management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Findings: • ↑AST ... /ALT (5-10x ULN) ... Intrahepatic Cholestasis Management ... obgyn #diagnosis #management
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
high fever, CRP, AST ... +ALT, ferritin. ... rheumatology #diagnosis #management
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
Transaminitis (AST ... , ALT) > 22% - ... #Pharmacology #Management
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary
Clinical features - Classic triad (flank pain, hematuria,
Diagnosis and Management ... Hypercalcemia 4. ↑ AST ... , ALT, and/or ALP ... RCC #Diagnosis #Management
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
ALT, alanine aminotransferase ... ; AST, aspartate ... algorithm #diagnosis #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
cytokines, such as ... function tests ↑ AST ... ↑ ALT ↑ bilirubin ... Syndrome #Diagnosis #Management
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Chemistry Tests - AST ... , ALT, Alkaline ... Bilirubin Metabolism AST ... and ALT: • AST ... liver, 80% of AST
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Hepatocellular Level • AST ... to liver than AST ... elevated ALP • AST ... NT: ↑ • ALP > AST ... • Near normal AST